6-Fluoro-4-chromanone (CAS number 66892-34-0) is a fluorinated heterocyclic compound that is a benzene-fused dihydropyran with a fluorine and a ketone substituent. The fluorine group enhances the lipophilicity of 6-fluoro-4-chromanone, and also favors further functionalization via nucleophilic aromatic substitution. Through this method, chromophoric xerogels are synthesized for sensor applications. The ketone substituent supports functionalization through an aldol reaction. 6-Fluoro-4-chromanone is also used as an enzyme inhibitor such as Sirtuin 2 (an enzyme related to aging diseases).
6-Fluoro-4-chromanone can be fully aromatized in an oxidation reaction catalyzed by iodine, to expand its application to DSSCs.