6-Fluoroindole-2-carboxylic acid (CAS number 3093-97-8) is a fluorinated indole derivative, having a fluorine at 6-position and a carboxylic acid at 2-position. The secondary amine and carboxylic acid in 6-Fluoroindole-2-carboxylic acid form an α-amino acid moiety. This allows 6-fluoroindole-2-carboxylic acid to have a zwitterionic form where the proton of the carboxylic acid is transferred to the amine. In fluorescence spectra, the neutral form and zwitterionic form of 6-fluoroindole-2-carboxylic acid have different emission band at 332 and 370 nm respectively, forming a broad fluorescence emission peak.
The carboxylic acid group in 6-fluoroindole-2-carboxylic acid can bind to copper(II), yielding a binuclear complex. The complex shows anti-cancer activity towards breast cancer cell lines (MDA-MB-231 and MCF-7) with percentage of inhibition of 90% at 20 µM concentration.
6-Fluoroindole-2-carboxylic acid can be used to synthesize triindoles, via a palladium catalyzed decarboxylative reaction. Triindoles are used as semiconductors in OFETs with field effect mobility of 0.03 cm2V-1S-1, as well as hole transport layers in solar cells.
Multiple functional groups
For facile synthesis
Fluorinated indole building block
For drug discovery, solar cells, and OLEDs
Worldwide shipping
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High purity
>98% High purity