5-Fluorooxindole (CAS number 56341-41-4), a fluorinated oxindole, is a benzene ring fused pyrrolidone (γ-lactam) with a fluorine substituent at 5-position. 5-Fluorooxindole has proven effectiveness on alleviating inflammatory pain and improving the analgesic effects of morphine. 5-Fluorooxindole inhibits the plasticity changes, oxidative stress, and inflammatory responses cause by peripheral inflammation. The derivatives of 5-fluorooxindole are used as α-glucosidase inhibitors for prevention and treatment of type 2 diabetes.
The 3-position of 5-fluorooxindole can be functionalized through an aldol condensation reaction in a basic solution. With the expanded chromophore, 5-fluorooxindole is used as an acceptor in dye-sensitized solar cells (DSSCs) with power conversion efficiency of 6.35%. Oxindole modified polymers are exploited as donors in non-fullerene polymer solar cells with Y6 (BTP-4F) as acceptor with power conversion efficiency up to 8.27%.