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3-(4 - 氟苯基)-1 - 异丙基吲哚

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产品名称: 3-(4 - 氟苯基)-1 - 异丙基吲哚
产品型号: 93957-49-4
产品展商: Ossila

简单介绍


3-(4 - 氟苯基)-1 - 异丙基吲哚  的详细介绍

3-(4-Fluorophenyl)-1-isopropylindole (CAS number 93957-49-4) is a derivative of indole, a heterobicyclic compound, with a 4-fluorophenyl (3-position) and an isopropyl substituent (1-position). 3-(4-Fluorophenyl)-1-isopropylindole is the nucleus of Fluvastatin, a drug used to treat hypercholesterolemia for preventing cardiovascular diseases. A series of 3-(4-Fluorophenyl)-1-isopropylindole derivatives are synthesized, presenting a significant decrease of serum total cholesterol, triglycerides, and low-density lipoprotein levels. The syntheses involve a Vilsmeier-Haack reaction for introducing an aldehyde to the 2-position and then a Claisen-Schmidt condensation for the modification of the aldehyde.

Chemical structure of Fluvastatin
Chemical structure of Fluvastatin, a drug for treating hypercholesterolemia

3-(4-Fluorophenyl)-1-isopropylindole also shows non-linear optical properties. The electron-withdrawing substituent of indole increases the hyperpolarizability coefficient, thus resulting a better non-linear optical response.


General Information


CAS Number 93957-49-4
Chemical Formula C17H16FN
Full Name 3-(4-Fluorophenyl)-1-isopropyl-1H-indole
Molecular Weight 253.32 g/mol
Synonyms 1-Isopropyl-3-(4-fluorophenyl)indole
Classification / Family Fluorinated building block, heterocyclic building block, APIs, Photonics

Chemical Structure


3-(4-Fluorophenyl)-1-isopropylindole chemical structure, CAS 93957-49-4
3-(4-Fluorophenyl)-1-isopropylindole chemical structure, CAS 93957-49-4

Product Details


Purity 97%
Melting Point Tm = 95 °C – 98 °C
Appearance Off-white to pale beige powder
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