7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid (CAS number 100361-18-0) is derived from naphthyridine, a bicyclic heterocyclic, bearing a chlorine (7-position), a fluorine (6-position), a cyclopropyl (1-position), a carbonyl (4-position) and a carboxylic acid (3-position). 7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid is an important intermediate for synthesizing Gemifloxacin, a quinolone antibiotic. It is also a molecular scaffold for many other active pharmaceutical ingredients (APIs) of anticancer and anti-inflammatory activities.
7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid has multiple metal-binding sides. The ketone and carboxylic acid form a 1,3-diketone moiety which binds transition metals to produce metal complexes. The drug-metal complexes show enhanced biological activity. The amines (1,8-position) in 7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid can also chelate to metal centers yielding complexes for APIs.