4-Chloro-7-trifluoromethylquinoline-3-carboxylic acid ethyl ester (CAS number 1168-42-3) is an ethyl ester of quinoline-3-carboxylic acid with both electron-withdrawing chloro and trifluoromethyl groups. Like other quinoline derivatives, 4-chloro-7-trifluoromethylquinoline-3-carboxylic acid ethyl ester is used as antimicrobials in medicinal chemistry research. Study suggests that attaching this building block to a cell-penetrating peptides causes the osmotic swelling of endosome, thus resulting an enhancement of cell penetration ability of the peptides. During the cell penetrating process, trifluoromethyl group binds with protons, followed by the increase of pH and destabilization of the cell membranes.
The lone pair on the amine can bind to metal centers forming dye complexes in application of dye-sensitized solar cells (DSSCs). The chloro substituent enables the further functionalization to the molecule such as forming a bidentate ligand for bioimaging and sensors.
Multiple functional groups
For facile synthesis
Fluorinated quinoline building block
For drug discoveries, dyes, and solar cells
Worldwide shipping
Quick and reliable shipping
High purity
>98% High purity
