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5‑溴‑2‑氟吡啶

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产品名称: 5‑溴‑2‑氟吡啶
产品型号: 766-11-0
产品展商: Ossila

简单介绍


5‑溴‑2‑氟吡啶  的详细介绍

5-Bromo-2-fluoropyridine (CAS number 766-11-0) is a halogenated pyridine bearing a bromine and a fluorine at 5- and 2-positions. 5-Bromo-2-fluoropyridine has been used as a molecular scaffold for many active pharmaceutical ingredients(APIs) such as inhibitors of neuropeptide Y receptor Y5, inhibitors of the main protease of SARS-CoV-2 and inhibitors of indoleamine-2,3-dioxygenase-1 in cancer immunotherapy. The bromine and fluorine substituents have different reactivity. Fluorine substituent is in favor of nucleophilic aromatic substitution, while bromine substituent prefers copper/palladium catalyzed C-C/C-N coupling.

5-Bromo-2-fluoropyridine is also an ideal building block for semiconductors, due to its aromaticity and electron deficiency. A host material of 5-(5-(2,4,6-triiso-propylphenyl)pyridin-2-yl)-5H-benzo[d]benzo-[4,5]imidazo[1,2-a]imidazole is synthesized from 5-bromo-2-fluoropyridine for OLED applications.


General Information


CAS Number 766-11-0
Chemical Formula C5H3BrFN
Full Name 5-Bromo-2-fluoropyridine
Molecular Weight 175.99 g/mol
Synonyms 3-Bromo-6-fluoropyridine
Classification / Family Fluorinated building block, Heterocyclic building block, Pyridine derivatives, Drug discovery, APIs, OLEDs

Chemical Structure


5-Bromo-2-fluoropyridine chemical structure
5-Bromo-2-fluoropyridine chemical structure, CAS 766-11-0

Product Details


Purity 98%
Boiling Point Tb = 162 – 164 °C at 760 mmHg
Relative Density 1.71 g/mL at 25 °C
Appearance Colorless liquid
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