2,4-Difluorobenzonitrile (CAS number 3939-09-1) is a benzonitrile derivative with two fluorine atoms at 2- and 4-positions. 2,4-Difluorobenzonitrile is commonly used as a molecular building block for introducing fluorinated benzonitrile to the target molecules by nucleophilic aromatic substitution. The reactive side is primarily on the para-position to the nitrile group, as it is less sterically hindered. 2,4-Difluorobenzonitrile functionalized triazolopyrimidine has been comprehensively studied on treatment of Alzheimer's disease.
2,4-Difluorobenzonitrile reacts with sodium azide for fluorinated tetrazole, a 5-membered ring heterocyclic with four nitrogen atoms. Fluorinated phenyltetrazole forms complexes with iridium showing blue light photoluminescence quantum yield up to 76%. The complexes are promising to be used in OLEDs and photoredox catalytic reactions.