1-Bis(4-fluorophenyl)methyl piperazine (CAS number 27469-60-9), also referred to as difluorobenzhydrylpiperazine, has a piperazine connecting to a diphenylmethane with two fluorine atoms at para-positions. 1-Bis(4-fluorophenyl)methyl piperazine appears in synthesis of drugs such as flunarizine and lomerizine. The diphenylpiperazine drugs are typically classified as calcium antagonists (calcium channel blockers) and used clinically for the treatment of migraines. The synthesis involves a one-step reaction of 1-bis(4-fluorophenyl)methyl piperazine with the halogenated analogs of the second fragments via nucleophilic substitution.
1-Bis(4-fluorophenyl)methyl piperazine also involves in synthesis of piperazinylacetamides for anticancer drugs, with half maxima growth inhibitory concentration (GI50) of 4.36 µM.