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1-Bis(4-fluorophenyl)methyl piperazine

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产品名称: 1-Bis(4-fluorophenyl)methyl piperazine
产品型号: 27469-60-9
产品展商: Ossila
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简单介绍


1-Bis(4-fluorophenyl)methyl piperazine  的详细介绍

1-Bis(4-fluorophenyl)methyl piperazine (CAS number 27469-60-9), also referred to as difluorobenzhydrylpiperazine, has a piperazine connecting to a diphenylmethane with two fluorine atoms at para-positions. 1-Bis(4-fluorophenyl)methyl piperazine appears in synthesis of drugs such as flunarizine and lomerizine. The diphenylpiperazine drugs are typically classified as calcium antagonists (calcium channel blockers) and used clinically for the treatment of migraines. The synthesis involves a one-step reaction of 1-bis(4-fluorophenyl)methyl piperazine with the halogenated analogs of the second fragments via nucleophilic substitution.

1-Bis(4-fluorophenyl)methyl piperazine also involves in synthesis of piperazinylacetamides for anticancer drugs, with half maxima growth inhibitory concentration (GI50) of 4.36 µM.


General Information


CAS Number 27469-60-9
Chemical Formula C17H18F2N2
Full Name 1-Bis(4-fluorophenyl)methyl piperazine
Molecular Weight 288.34 g/mol
Synonyms 1-(4,4'-Difluorobenzhydryl)piperazine, 1-(4,4'-Difluorodiphenylmethyl)piperazine, 4,4'-Difluorobenzhydrylpiperazine
Classification / Family Fluorinated building block, Heterocyclic building block, APIs, antimicrobials

Chemical Structure


1-Bis(4-fluorophenyl)methyl piperazine chemical structure, CAS 27469-60-9.
1-Bis(4-fluorophenyl)methyl piperazine chemical structure, CAS 27469-60-9

Product Details


Purity 98%
Melting Point Tm = 88 °C – 92 °C
Appearance White powder
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