2-Fluoropyridine-3-carbonitrile (CAS number 3939-13-7), also named as 2-fluoronicotinonitrile, is a nicotinonitrile building block featuring a fluoride substituent at 2-position. 2-Fluoropyridine-3-carbonitrile commonly serves as a synthesis precursor for active pharmaceutical ingredients (APIs), such as niflumic acid that is used for joint and muscular pain relief. Pyrazopyridine, a bicyclic heterocycle can be synthesized from 2-fluoropyridine-3-carbonitrile. The reaction begins with a nucleophilic aromatic substitution of hydrazine, followed by a pyrazole cyclization reaction.
Additionally, 2-fluoropyridine-3-carbonitrile can be modified through Minisci reaction for meta- and para-alkylation.