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6 - 氟吡啶 - 2 - 羧酸甲酯

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产品名称: 6 - 氟吡啶 - 2 - 羧酸甲酯
产品型号: 455-71-0
产品展商: Ossila

简单介绍


6 - 氟吡啶 - 2 - 羧酸甲酯  的详细介绍

Methyl 6-fluoropyridine-2-carboxylate (CAS number 455-71-0, also known as methyl 6-fluoropicolinate, is a pyridine derivative with a methyl carboxylate at 2-position and a fluoride at 6-position. Methyl 6-fluoropyridine-2-carboxylate is readily used to functionalize molecular scaffolds for synthesizing active pharmaceutical ingredients (APIs), through nucleophilic aromatic substitution on the fluoride group. A selective antagonist of BCL-XL for chronic lymphocytic leukaemia treatment is synthesized from methyl 6-fluoropyridine-2-carboxylate, showing a potency of 14 nM.

Once methyl 6-fluoropyridine-2-carboxylate is hydrolysed, it becomes a bidentate chelating agent. A Ru-fluoropyridine-2-carboxylate complex shows cytotoxicity of 27.5 µM in antitumour activity. Hydrolysed methyl 6-fluoropyridine-2-carboxylate is also employed as a ligand in palladium-catalyzed C-H acetoxylation of arenes.

General Information


CAS Number 455-71-0
Chemical Formula C7H6FNO2
Full Name Methyl 6-fluoro-2-pyridinecarboxylate
Molecular Weight 155.13 g/mol
Synonyms Methyl 6-fluoropicolinate, 6-Fluoro-2-pyridinecarboxylic acid methyl ester
Classification / Family Fluorinated building blocks, Pyridine building blocks, Ligands, Catalysts, APIs

Chemical Structure


Methyl 6-fluoropyridine-2-carboxylate chemical structure, CAS 455-71-0.
Methyl 6-fluoropyridine-2-carboxylate chemical structure, CAS 455-71-0

Product Details


Purity 98%
Melting Point Tm = 51 °C – 55 °C
Appearance Off-white crystals
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