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2,3,5,6 - 四氟 - 4 - 羟基苯甲酸

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产品名称: 2,3,5,6 - 四氟 - 4 - 羟基苯甲酸
产品型号: 652-34-6
产品展商: Ossila

简单介绍


2,3,5,6 - 四氟 - 4 - 羟基苯甲酸  的详细介绍

2,3,5,6-Tetrafluoro-4-hydroxybenzoic acid (CAS number 652-34-6) is a perfluorinated para-hydroxybenzoic acid building block. Due to its perfluorination, 2,3,5,6-tetrafluoro-4-hydroxybenzoic acid is relatively acidic with an observed pKa of 5.3, compared to non-fluorinated 4-hydroxybenzoic acid (pKa of 9.3). 2,3,5,6-Tetrafluoro-4-hydroxybenzoic acid is a precursor used to synthesize BMV109 which serves as a fluorescent activity-based probe for bioimaging. This probe is intrinsically non-fluorescent but only becomes fluorescent after reacting with a target protease.

2,3,5,6-Tetrafluoro-4-hydroxybenzoic acid is also employed in the preparation of novel inhibitors for protein farnesyltransferase (FTase) and geranylgeranyltransferase (GGTase), through Mitsunobu reaction. Enzyme inhibition studies demonstrate a potency of 2.9 µM against FTase and 7.5 µM against GGTase.

General Information


CAS Number 652-34-6
Chemical Formula C7H2F4O3
Full Name 2,3,5,6-Tetrafluoro-4-hydroxybenzoic acid
Molecular Weight 210.08 g/mol
Synonyms 4-Carboxy-2,3,5,6-tetrafluorophenol, 4-Hydroxy-2,3,5,6-tetrafluorobenzoic acid
Classification / Family Fluorinated building blocks, Benzoic acid building blocks, APIs, Bioimaging

Chemical Structure


2,3,5,6-Tetrafluoro-4-hydroxybenzoic acid chemical structure, CAS 652-34-6.
2,3,5,6-Tetrafluoro-4-hydroxybenzoic acid chemical structure, CAS 652-34-6

Product Details


Purity 98%
Melting Point Tm = 151 °C – 153 °C
Appearance White powder
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