1-(3-Fluorophenyl)-1H-pyrazole-4-carbaldehyde (CAS number 936940-82-8) is a pyrazole derivative substituted with a 3-fluorophenyl and an aldehyde group. Pyrazole derivatives are widely utilized as active pharmaceutical ingredients (APIs) including celecoxib. A novel anti-inflammatory pyrazole derivative, LQFM021, incorporates 1-(3-fluorophenyl)-1H-pyrazole-4-carbaldehyde in its synthesis. The entire synthesis process takes two steps: the functional group conversion of the aldehyde group to a nitrile and the formation of a tetrazole using sodium azide.
1-(3-Fluorophenyl)-1H-pyrazole-4-carbaldehyde is also employed in the synthesis of a pyrazole-based disubstituted urea, serving as an anti-melanoma agent.