4-Amino-2-(trifluoromethyl)pyridine (CAS number 147149-98-2) has an amine and a trifluoromethyl group substituted on its pyridine core. 4-Amino-2-(trifluoromethyl)pyridine are involved in many syntheses of active pharmaceutical ingredients (APIs), such as naporafenib, a RAF inhibitor used in the treatment of RAF-driven cancers. 4-Amino-2-(trifluoromethyl)pyridine can also be used for synthesizing pyridine-based ligands to stabilize hypervalent iodine which is applied in a wide range of synthetic transformations.
4-Amino-2-(trifluoromethyl)pyridine can undergo a Chichibabin reaction to introduce an additional amine group in the para-position. The resulting product is employed in the synthesis of oral checkpoint kinase inhibitor for immunotherapy.