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4-Amino-2-(trifluoromethyl)pyridine

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产品名称: 4-Amino-2-(trifluoromethyl)pyridine
产品型号: 147149-98-2
产品展商: Ossila

简单介绍


4-Amino-2-(trifluoromethyl)pyridine  的详细介绍

4-Amino-2-(trifluoromethyl)pyridine (CAS number 147149-98-2) has an amine and a trifluoromethyl group substituted on its pyridine core. 4-Amino-2-(trifluoromethyl)pyridine are involved in many syntheses of active pharmaceutical ingredients (APIs), such as naporafenib, a RAF inhibitor used in the treatment of RAF-driven cancers. 4-Amino-2-(trifluoromethyl)pyridine can also be used for synthesizing pyridine-based ligands to stabilize hypervalent iodine which is applied in a wide range of synthetic transformations.

4-Amino-2-(trifluoromethyl)pyridine can undergo a Chichibabin reaction to introduce an additional amine group in the para-position. The resulting product is employed in the synthesis of oral checkpoint kinase inhibitor for immunotherapy.

General Information


CAS Number 147149-98-2
Chemical Formula C6H5F3N2
Full Name 2-(Trifluoromethyl)-4-pyridinamine
Molecular Weight 162.11 g/mol
Synonyms 2-(Trifluoromethyl)pyridin-4-amine, 2-Trifluoromethyl-4-amino-pyridine
Classification / Family Fluorinated building blocks, Heterocyclic building blocks, Pyridine building blocks, APIs, Ligands

Chemical Structure


4-Amino-2-(trifluoromethyl)pyridine chemical structure, CAS 147149-98-2.
4-Amino-2-(trifluoromethyl)pyridine chemical structure, CAS 147149-98-2

Product Details


Purity 98%
Melting Point Tm = 58 °C – 62 °C
Appearance White crystals
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