4-Bromo-6-fluoroquinoline (CAS number 661463-17-8) is a dihalogenated quinoline, a benzene-fused pyridine bicyclic heterocycle. Quinoline derivatives are widely used as active pharmaceutical ingredients (APIs). 4-Bromo-6-fluoroquinoline is applied in the synthesis of linrodostat, an inhibitor of indoleamine 2,3-dioxygenase for anti-cancer treatments. The reactivity of 4-bromo-6-fluoroquinoline includes Pd-catalyzed coupling reactions on the bromide group and nucleophilic aromatic substitution on the fluoride group.
As an aromatic bicyclic compound, 4-bromo-6-fluoroquinoline can also be used in the preparation of dyes for the applications of OLEDs and solar cells.