3-Fluoro-p-anisidine (CAS number 366-99-4), also referred to as 3-fluoro-4-methoxyaniline, is an aniline with a fluoride and a methoxy substituted at 3- and 4-positions. 3-Fluoro-p-anisidine is commonly used as a precursor for synthesizing quinoline derivatives through Combes quinoline synthesis with 1,3-diketones. The as synthesized quinoline derivatives are employed as active pharmaceutical ingredients and dyes. 3-Fluoro-p-anisidine is readily attached to molecular scaffolds through nucleophilic substitution.
The primary amine in 3-fluoro-p-anisidine can be used to prepare azides for copper-catalyzed azide-alkyne cycloaddition (click reaction).