α,α-Difluorophenylacetic acid (CAS number 360-03-2) is a phenyl acetic acid with two fluorides on the benzylic carbon. The inductive effect of the difluoromethyl group increases the acidity of α,α-difluorophenylacetic acid. α,α-Difluorophenylacetic acid is primarily used to introduce benzylic difluoromethylene group to molecular scaffolds through radical decarboxylative reaction. The reaction begins with an oxidative decarboxylation with persulfate forming a difluorobenzyl radical that is stabilized by the benzene and fluorine groups. The addition is carried out by the attack of the radical species to the alkenes or imines. The decarboxylative reaction is versatile and can even be performed in an aqueous solution.