2-Fluoro-4-nitroaniline, (CAS number 369-35-7) is an aniline derivative bearing a fluoride and a nitro group at 2- and 4-positions. 2-Fluoro-4-nitroaniline serves as a versatile molecular scaffold for synthesizing active pharmaceutical ingredients (APIs). The amine group conducts nucleophilic substitution and diazotization. The nitro group can be laterally reduced to amine for further reactions. A precursor to the antibiotic candidate TBI-233 is synthesized from 2-fluoro-4-nitroaniline.
2-Fluoro-4-nitroaniline was used to introduce sp3 defects onto semiconducting single-walled carbon nanotubes (SWCNTs) for organic color center-tailored carbon nanotubes. A lithium bismaleamate anode material is synthesized from 2-fluoro-4-nitroaniline, demonstrating an electrode capacity of 688.9 mAhg−1.