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4 - 氯 - 3 - 氟苯胺

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产品名称: 4 - 氯 - 3 - 氟苯胺
产品型号: 367-22-6
产品展商: Ossila

简单介绍


4 - 氯 - 3 - 氟苯胺  的详细介绍

4-Chloro-3-fluoroaniline (CAS number 367-22-6) is an aniline derivative featuring chloride and fluoride substituents at para- and meta-positions. 4-Chloro-3-fluoroaniline serves as a building block in the synthesis of antimalarial agents, wherein it undergoes nucleophilic substitution reactions. The incorporation of chloride and fluoride substituents significantly improves the drug’s potency, reducing the half maximal effective concentration (EC50) down to 27 nM against Plasmodium falciparum parasite. The utility of 4-chloro-3-fluoroaniline building block can be found in many active pharmaceutical ingredients (APIs) such as piperidine derivatives for antiviral treatments and quinazolines as anticancer agents.

Additionally, 4-chloro-3-fluoroaniline is also an optimal monomer for synthesizing fluorinated polyanilines, via Buchwald-Hartwig amination.

General Information


CAS Number 367-22-6
Chemical Formula C6H5ClFN
Full Name 4-Chloro-3-fluoroaniline
Molecular Weight 145.56 g/mol
Synonyms 4-Chloro-3-fluorophenylamine, 4-chloro-3-fluorobenzenamine
Classification / Family Fluorinated building blocks, Aniline building blocks, APIs, Semiconductors

Chemical Structure


4-Chloro-3-fluoroaniline chemical structure, CAS 367-22-6.
4-Chloro-3-fluoroaniline chemical structure, CAS 367-22-6

Product Details


Purity 98%
Melting Point Tm = 58 °C – 62 °C
Appearance Grey powder/crystals
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