2,4,5-Trifluorobenzonitrile (CAS number 98349-22-5) has three fluorides substituting on the benzonitrile core. 2,4,5-Trifluorobenzonitrile serves as a building block for introducing a fluorinated benzonitrile segment to the target molecule by nucleophilic aromatic substitution. A fluorinated analog of platensimycin, an antibiotic, can be readily synthesized from 2,4,5-trifluorobenzonitrile resulting in a overall yield of 23% over eight steps.
2,4,5-Trifluorobenzonitrile is also employed in the synthesis of dinitrile monomers for polytriazine covalent organic frameworks (COFs). These COFs exhibit BET surface area of 733 m2/g, along with a gas selectivity (CO2/N2) of 48.7 ± 1.2 at 272 K.