4-Fluoro-2-methylphenol (CAS number 452-72-2), also knowns as 4-fluoro-o-cresol, is a para-fluorinated o-cresol. 4-Fluoro-2-methylphenol commonly serves as a building block for active pharmaceutical ingredients (APIs). Compared to non-substituted phenol, 4-fluoro-2-methylphenol offers selective inhibition over receptor tyrosine kinase and improves hepatocyte stability in quinazolines.
A tetradentate aminophenol ligand can be prepared from 4-fluoro-2-methylphenol, ethanolamine and formaldehyde via thermal Mannich condensation. A ligand-to-metal charge transfer (LMCT) complex synthesized from the aminophenol ligand and vanadium, demonstrates a charge transfer state with a lifetime of 423 ps. The long-lived LMCT complex is ideal for driving photochemical reactions. Furthermore, 4-Fluoro-2-methylphenol can be grafted onto natural polymer such as fax and coconut fibers catalyzed by laccase for the modification of hydrophobicity.