3,5-Difluoropyridine-2-carbonitrile (CAS number 298709-29-2), also knowns as 3,5-difluoropicolinonitrile, is a difluorinated cyanopyridine. 3,5-Difluoropyridine-2-carbonitrile is highly electron deficient, thus the fluorine substituents readily undergo nucleophilic aromatic substitution reactions. A thermally activated delayed fluorescence (TADF) emitter, known as 2,4-2(9H-carbazol-9-yl)-1-cyano-pyridine, is prepared using this method, demonstrating maximum current, power and external quantum efficiency values of 27.5 cdA-1, 25.6 lmW-1 and 9.1%, respectively, in OLED application.
3,5-Difluoropyridine-2-carbonitrile finds extensive applications as a molecular scaffold in medicinal chemistry such as the synthesis of thiazole analogs for desferrithiocin.