2-Fluoro-4-(trifluoromethyl)benzoic acid (CAS number 115029-24-8) is a benzoic acid derivative featuring a fluoride and a trifluoromethyl substituents at 2- and 4-positions. As a synthetic building block, 2-fluoro-4-(trifluoromethyl)benzoic acid can be easily attached to molecular scaffolds through condensation reactions. A structure-activity relationship study has indicated that the trifluoromethyl and fluoride group introduced by 2-fluoro-4-(trifluoromethyl)benzoic acid improve the agonistic activity of G protein-coupled receptors. The increased potency results from the halogen bonding interaction of the fluorinated groups and proteins.
2-Fluoro-4-(trifluoromethyl)benzoic acid can also undergo functional group exchanges to afford acyl chlorides, aldehydes and anhydrides.