5-Bromo-2-fluoropyrimidine (CAS number 62802-38-4) is a derivative of pyrimidine, a 6-membered heterocycle with two nitrogen heteroatoms. 5-Bromo-2-fluoropyrimidine has bromide and fluoride substituents at the para-position, enabling it for synthesizing linear macromolecules under stepwise process. 5-Bromo-2-fluoropyrimidine can perform nucleophilic aromatic substitution on the fluoride group, Pd-catalyzed carbon-carbon coupling on the bromide group and acid-catalyzed vicarious nucleophilic substitution at the 4- and 6-positions. Thus, 5-bromo-2-fluoropyrimidine is used to prepare push-pull molecules, serving as an 'electron-pulling' moiety.
5-Bromo-2-fluoropyrimidine is also an essential building block for synthesizing reldesemitiv, a fast skeletal muscle troponin activator for treatment of diseases that lead to diminished muscle function.